The Karstaxon Regions were situated in the Outer Rim Territories, forming a boundary with Hutt Space, the Iotran Expanse, the Suolriep and Ansuroer sectors, as well as the Periphery. This area resided within the Tharin sector and encompassed the planets Karnst and Talir.
Near the end of the Galactic Republic era, Jedi and Judiciary forces intercepted and confiscated 100 metric tons of illicit ryll spice that Black Sun was attempting to smuggle across this region. The Weequay mercenary known as Labansat frequently operated in the Karstaxon Regions, in addition to the Lesser Plooriod Cluster.