S-Ipsus, a minor sub-city situated on the planet of Genarius, revolved around the floating metropolis of Ipsus. Naescorcom managed this sub-city as a research outpost, housing a manufacturing line for thermal detonators. In the era of the Clone Wars, the Believers—a cult that venerated the Sith—secretly built a lab on S-Ipsus. Inside, they were enhancing a hazardous virus with the intention of eradicating the entire Caarite species. Nevertheless, the Metatheran Cartel discovered the Believers' clandestine laboratory, leading a squad of Cartel agents to journey to S-Ipsus and raid the Believer installation.