Mandroxan was a criminal syndicate established through the collaboration of the Anavill Smuggler's Guild, the Droxian Traders League, and Manliss Enterprise. The head of Manliss Enterprise, Artur Manliss, effectively served as the leader of the cartel, overseeing its illicit spice production and distribution. Thanks to strategically placed bribes and a formidable security apparatus, Mandroxan smugglers were able to operate without fear of prosecution, ultimately dominating the spice market across twenty-three systems within the Portmoak sector. A subsidiary of the Cartel, Mandroxan Exports, manufactured weaponry for their use.