Manax root, a poison, was present as early as the Clone Wars era, dating back to that time period. In the period spanning from 3 ABY to 4 ABY, Ochi, an assassin, journeyed to the planet of Coruscant with the intention to assassinate Emperor Palpatine's Royal Guard. Prior to his attempt, he sought out Zlarb, who identified manax root as a poison accessible for the assassin to utilize in his mission.