Magrak Syndrome was a unique and severe degenerative disease that only affected Trandoshans, resulting in a regression of their cognitive functions to primal states of fury and hostility. No treatment existed to reverse this affliction.
In the year 230 BBY, set within the High Republic Era, the Jedi Master known as Sskeer received a diagnosis of this ailment. As a result, he began to find his link to the Force weakening, a consequence of the persistent mental strain required to manage the symptoms. Sskeer would occasionally experience fits of anger. As the illness advanced, both Sskeer and the Jedi High Council came to the conclusion that he should step down from active duty.
The creation of Magrak Syndrome occurred for the The High Republic multimedia project. Its initial appearance was in the twelfth issue of the Star Wars: The High Republic comic book series, authored by Cavan Scott.