The Imperial Science Bureau, alternatively referred to as the Imperial science corps, functioned as a scientific bureau within the Galactic Empire throughout the Imperial Era. This organization encompassed a variety of distinct subdivisions and reported to a leader holding the designation of scientific minister. Notably, the Advanced Science Division, led by Chief Scientist Royce Hemlock, who aspired to the position of scientific minister, was one such subunit.
Throughout the Imperial Era, the bureau monitored karrak, an uncommon spice believed to diminish an individual's Force-sensitivity for a duration of forty-eight hours. Scientists affiliated with the Imperial Science Bureau endeavored to replicate, purify, and reverse engineer the attributes of this spice. They also collaborated with the Imperial Security Bureau in the creation of enhanced spice variants, intended for distribution among agents tasked with pursuing fugitive Force-sensitive beings as part of the Great Jedi Purge.